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2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic and phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin. 2C-E is commonly known as "Europa" and is typically found as a white crystalline powder. [1] It is commonly active in the 10–20 mg range, taken orally, and highly dose-sensitive. Insufflating (administering the chemical nasally) requires a much lower dose, typically not exceeding 5 mg, but this method of consumption elicits a noticeably painful or uncomfortable sensation in the nasal cavity for 10 minutes or so.

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Shulgin classified 2C-E as a member of the "magical half-dozen" in his book PiHKAL (Phenethylamines I Have Known And Loved). Many have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense. Vivid hallucinations similar to those experienced while under the influence of LSD are common, and many reports indicate that the effects of this particular chemical may be overly intense for those not well experienced with psychedelics.[2]

See also: 2c-i